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Frequently Asked Questions

What are the side effects of brimonidine (Alphagan, Alphagan P)?

Short Answer

Eye discomfort, blurred vision, dizziness, dry mouth, drowsiness, or tiredness are some of the effects that may occur.

Long Answer

Brimonidine (bri MO ni deen) ophthalmic solution, sold as (Alphagan, Alphagan-P), is an eye drop that is used to treat conditions such as ocular hypertension or open-angle glaucoma.

Brimonidine side effects are similar to other similar eye drops: eye irritation (redness, swelling, blurred vision), sensitivity to light, and itchiness of the eye.

Other effects can be found in the reference links below.

Additional Information

eMedicineHealth: brimonidine ophthalmic (Pronunciation: bri MO ni deen)
Less serious side effects may include:
  • burning, stinging, or itching of your eyes;
  • feeling like something is in your eye;
  • blurred vision;
  • redness of the eye or eyelid;
  • mildly swollen or puffy eyes;
  • sensitivity to light;
  • nausea, upset stomach;
  • headache, dizziness;
  • muscle pain;
  • tired feeling;
  • sleep problems (insomnia);
  • dry nose or mouth; or
  • unusual or unpleasant taste in your mouth.
Call your doctor at once if you have any of these serious side effects:
  • slow or uneven heart rate;
  • pounding heartbeats or fluttering in your chest;
  • shallow breathing, feeling like you might pass out;
  • severe swelling, redness, or discomfort in or around your eye;
  • eye pain or increased watering; or
  • numbness or tingly feeling in your hands or feet.
DrugLib.com: Alphagan P (Brimonidine Ophthalmic) - Reports of Side Effects and Adverse Reactions
This is an index of reports of adverse events (side effects, adverse reactions, etc.) related to Alphagan P (Brimonidine Ophthalmic). Click on the relevant link below to view a selection of reports according to the event's seriousness level and/or the nature of the side effect / adverse reaction. Or scroll down to view all available reports.
PDR Health: Alphagan P - Generic name: Brimonidine tartrate
What should I tell my doctor before I take the first dose of Alphagan P? Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Alphagan P. Also, talk to your doctor about your complete medical history, especially if you have heart disease, circulation problems, Raynaud's disease, thromboangiitis obliterans, low blood pressure, depression, and liver or kidney problems.
What are possible food and drug interactions associated with Alphagan P? If Alphagan P is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Alphagan P with the following: alcohol, antidepressants, barbiturates such as phenobarbital, sleep medications, narcotic painkillers, blood pressure medications, and medications used to treat heart problems such as angina or heart failure. Alphagan P should never be combined with MAOIs, such as the antidepressants phenelzine and tranylcypromine
What are the possible side effects of Alphagan P? Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Alphagan P. Side effects may include: eye redness or irritation, inflamed or swollen eyelids, itchy eyes, burning sensation, conjunctival folliculosis, high blood pressure, allergic reaction, oral dryness, visual disturbance
Drugs.com: Alphagan P Side Effects
Adverse events occurring in approximately 10-20% of the subjects receiving brimonidine ophthalmic solution (0.1-0.2%) included: allergic conjunctivitis, conjunctival hyperemia, and eye pruritus. Adverse events occurring in approximately 5-9% included: burning sensation, conjunctival folliculosis, hypertension, ocular allergic reaction, oral dryness, and visual disturbance.
Adverse events occurring in approximately 1-4% of the subjects receiving brimonidine ophthalmic solution (0.1-0.2%) included: allergic reaction, asthenia, blepharitis, blepharoconjunctivitis, blurred vision, bronchitis, cataract, conjunctival edema, conjunctival hemorrhage, conjunctivitis, cough, dizziness, dyspepsia, dyspnea, epiphora, eye discharge, eye dryness, eye irritation, eye pain, eyelid edema, eyelid erythema, fatigue, flu syndrome, follicular conjunctivitis, foreign body sensation, gastrointestinal disorder, headache, hypercholesterolemia, hypotension, infection (primarily colds and respiratory infections), insomnia, keratitis, lid disorder, pharyngitis, photophobia, rash, rhinitis, sinus infection, sinusitis, somnolence, stinging, superficial punctate keratopathy, tearing, visual field defect, vitreous detachment, vitreous disorder, vitreous floaters, and worsened visual acuity.
The following events were reported in less than 1% of subjects: corneal erosion, hordeolum, nasal dryness, and taste perversion.