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Frequently Asked Questions

Can dapoxetine hydrochloride help with premature ejaculation (PE)?

Short Answer

Dapoxetine hydrochloride was originally an antidepressant drug. Researchers discovered it had an interesting side effect: it helps with PE.

Long Answer

Other PE treatments include off-label use of selective serotonin reuptake inhibitors (SSRIs) as well as topical anesthetics to reduce sensitivity.

Dapoxetine is a fast-acting serotonin transporter inhibitor that was under US Food and Drug Administration review as a treatment for premature ejaculation. Alza Corporation submitted dapoxetine for FDA approval in December 2004 but was turned down in October 2005.

Dapoxetine would have been the first drug specifically indicated for PE in the United States and would be marketed by Ortho-McNeil Pharmaceutical, Inc. In a press release, Alza stated that it plans to address questions raised in the FDA letter and continue the development program.

Selective serotonin reuptake inhibitors are normally used to treat depression and other psychiatric disorders. Some have been used for treating premature ejaculation because one of their side effects is to delay ejaculation. Continued SSRI use may have some negative side effects including: psychiatric problems, skin reactions, weight gain, and loss of libido. Possible side effects of dapoxetine include: dizziness, nausea, insomnia, headache, and diarrhea.

People searching for SSRI also searched for:

  • citalopram (Celexa, Cipramil, Emocal, Sepram)
  • dapoxetine
  • escitalopram oxalate (Lexapro, Cipralex, Esertia)
  • fluoxetine (Prozac, Fontex, Seromex, Seronil, Sarafem, Fluctin)
  • fluvoxamine maleate (Luvox, Faverin)
  • paroxetine (Paxil, Seroxat, Aropax, Deroxat)
  • sertraline (Zoloft, Lustral, Serlain)

Additional Information